Health Canada is informing consumers of potential risks related to the combination of methylisothiazolinone and methylchloroisothiazolinone (MI/MCI) used as a preservative in certain leave-on cosmetic, non-prescription and natural health products. Examples of leave-on products include skin moisturizers, massage products, make-up, antiperspirants/deodorants, sunscreen lotions, antiseptic cleansers, topical pain relief, acne creams and diaper rash products. For some people, use of these substances can lead to symptoms including: a red rash or bumps; itching (which may be severe); swelling, burning, or tenderness of the skin; dry, cracked or scaly skin; and/or blisters (draining fluid and crusting). These symptoms may occur each time someone uses a product containing MI/MCI and may become more severe with repeated use. These preservatives are also used in rinse-off products, such as shampoos and shower gels. Based on current information, there are no identified risks with the use of MI/MCI in rinse-off products when concentrations are at or below levels currently permitted in cosmetics.